ChemoCentryx commences CCX140 Stage II trial in diabetic nephropathy ChemoCentryx.

ChemoCentryx commences CCX140 Stage II trial in diabetic nephropathy ChemoCentryx, Inc migraine-headaches-essence-of-the-disorder.html . Announced the initiation of a Phase II scientific trial for CCX140 today, an orally-administered small molecule for the treatment of diabetic kidney disease . CCX140 functions by blocking the infiltration and activation of particular populations of monocyte and macrophages and other cells bearing CCR2 occurring during inflammation. As a precursor to the initiated clinical trials for CCX140 in sufferers with diabetic nephropathy recently, in an earlier Phase II clinical trial, ChemoCentryx assessed the security, tolerability and clinical effects of CCX140 in type 2 diabetics with regular kidney function. ‘Previously we demonstrated that CCX140 could possibly be used in sufferers with type 2 diabetes in a clinical trial where it had been safe and well tolerated and demonstrated the capability to control glycemic indices. Upon effective completion of the Phase II plan in diabetic nephropathy with CCX140, our lead independent drug applicant, we plan to expeditiously initiate Phase III clinical advancement,’ stated Thomas Schall, Ph.D. President & CEO, ChemoCentryx.’.

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